View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
TUESDAY, Jan. 17 (HealthDay News) -- The major components of coffee are able to inhibit the toxic aggregation of human islet amyloid polypeptide (hIAPP), according to a study published in the Dec. 28 issue of the Journal of Agricultural and Food Chemistry.
Biao Cheng, from Huazhong University of Science and Technology in Wuhan, China, and colleagues investigated the effects of the major components of coffee (caffeine, caffeic acid, and chlorogenic acid) and dihydrocaffeic acid on the amyloidogenicity of hIAPP.
The researchers found that all coffee components exhibited inhibitory effects on toxic hIAPP amyloid formation, with caffeic acid showing the highest potency in delaying conformational transition with the most prolonged lag time, and caffeine exhibiting the lowest potency. All components affected the secondary structure of incubated hIAPP at a five-fold excess molar ratio of compound to hIAPP. Caffeic acid and chlorogenic acid, but not caffeine, significantly inhibited the formation of hIAPP oligomers. All three coffee components showed cell protection effects, with caffeic acid the most, and chlorogenic acid the least, potent.
"These findings suggest that the beneficial effects of coffee consumption on type 2 diabetes mellitus may be partly due to the ability of the major coffee components and metabolites to inhibit the toxic aggregation of hIAPP," the authors write.
Full Text (subscription or payment may be required)
Find in-depth content on major issues provided by leading companies in partnership with NursingCenter.com
BD Safety Beyond Needlestick Prevention Learning Center
Sponsored by BD Medical
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top