View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
TUESDAY, Jan. 17 (HealthDay News) -- Although extracellular matrix (ECM) expression in the airway smooth muscle (ASM) layer is not different for patients with asthma and controls, it is associated with the dynamics of airway function in patients with asthma, according to a study published online Jan. 9 in Allergy.
Ching Yong Yick, from the Academic Medical Center in Amsterdam, Netherlands, and colleagues conducted a cross-sectional study on airway dynamics of 19 patients with atopic mild asthma, 15 healthy atopic controls, and 12 healthy nonatopic controls. Tests performed included spirometry, methacholine responsiveness, deep-breath-induced bronchodilation (ΔRrs), and bronchoscopy with endobronchial biopsies. Biopsy samples were analyzed using histochemical and immunohistochemical assays.
The researchers found that there were no significant differences in the ECM expression in ASM between patients with asthma and controls. The fractional area and mean density of collagen I and III were significantly associated with the slope of methacholine dose-response and with ΔRrs. In patients with asthma, there was a significant association for both ASM collagen III and laminin with forced expiratory volume in one second.
"In asthma, ECM in ASM is related to the dynamics of airway function in the absence of differences in ECM expression between asthma and controls. This indicates that the ASM layer in its full composition is a major structural component in determining variable airways obstruction in asthma," the authors write.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top