No Autoimmune Safety Signal for Quadrivalent HPV Vaccine

Women vaccinated with HPV4 have no increase in incidence of 16 autoimmune disorders

FRIDAY, Jan. 20 (HealthDay News) -- For women vaccinated with the quadrivalent human papillomavirus vaccine (HPV4), there is no evidence of an autoimmune safety signal, according to a study published in the February issue of the Journal of Internal Medicine.

Chun Chao, Ph.D., from Kaiser Permanente Southern California in Pasadena, and colleagues conducted an observational study to assess the safety of HPV4 in women. A total of 189,629 women, who received one or more doses of HPV4 between August 2006 and March 2008, were followed for 180 days after each dose to identify new diagnoses of 16 prespecified autoimmune conditions. The incidence of each autoimmune condition observed in vaccinated women was compared with the incidence estimated for unvaccinated women at one study site.

The investigators identified 1,014 potential new-onset cases, of which 719 were eligible for review and 31 to 40 percent were confirmed. There were no clusters of disease onset in relation to vaccination. There was a significant increase only in the incidence rate ratio (IRR) for Hashimoto's disease (IRR, 1.29; 95 percent confidence interval, 1.08 to 1.56), but there was no consistent evidence for a safety signal for autoimmune thyroid conditions.

"This observational surveillance study offers some assurance that amongst a large and likely generalizable female population, no safety signal for autoimmune conditions was found following HPV4 vaccination in routine clinical use," the authors write.

Several authors disclosed financial ties with pharmaceutical companies, including Merck & Co., which partially funded the study.

Abstract
Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Meeting the Needs of Family Members of ICU Patients
Critical Care Nursing Quarterly, October/December 2014
Free access will expire on December 22, 2014.


Dealing with the specter of phantom limb pain
Nursing2014 , November 2014
Free access will expire on December 8, 2014.


The Power of Nursing Peer Review
JONA: Journal of Nursing Administration, November 2014
Free access will expire on December 8, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events