Men at Higher Risk for Mild Cognitive Impairment

Incidence of amnestic and nonamnestic mild cognitive impairment higher in men than women

WEDNESDAY, Jan. 25 (HealthDay News) -- The incidence of both amnestic and nonamnestic mild cognitive impairment (aMCI and naMCI) is higher in men than women, according to a study published online Jan. 25 in Neurology.

Rosebud O. Roberts, M.B., Ch.B., of the Mayo Clinic in Rochester, Minn., and colleagues conducted a population-based prospective cohort study involving 1,450 subjects aged 70 to 89 years who were cognitively normal at baseline. Participants underwent a neurologic evaluation, neuropsychological testing, and an evaluation using the Clinical Dementia Rating scale at baseline and 15-month intervals.

The researchers found that 296 of the participants developed MCI, for an age- and sex-standardized incidence rate of 63.6 per 1,000 person-years. The incidence of MCI was higher in men than for women (72.4 versus 57.3 per 1,000 person-years). The overall incidence of aMCI was higher than naMCI (37.7 versus 14.7 per 1,000 person-years). The rates of both aMCI and naMCI were higher in men than women (43.9 versus 33.3 for aMCI and 20.0 versus 10.9 for naMCI) and higher in those with 12 or fewer years of education compared with those with higher education levels (42.6 versus 32.5 for aMCI and 20.3 versus 10.2 for naMCI).

"The incidence rates for MCI are substantial. Differences in incidence rates by clinical subtype and by sex suggest that risk factors for MCI should be investigated separately for aMCI and naMCI, and in men and women," the authors write.

Several authors disclosed financial ties to the pharmaceutical, biotechnology, and health care industries.

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