Dutasteride Delays Low-Risk Prostate Cancer Progression

Men under active surveillance for low-risk prostate cancer benefit from adjunct dutasteride

TUESDAY, Jan. 24 (HealthDay News) -- For men with low-risk prostate cancer who undergo active surveillance, treatment with dutasteride delays the time to cancer progression, according to a study published online Jan. 24 in The Lancet.

Neil E. Fleshner, M.D., M.P.H., from the University of Toronto, and colleagues conducted a randomized, double-blind, placebo-controlled study to investigate the safety and efficacy of dutasteride, a 5α-reductase inhibitor, for men with low-risk prostate cancer. Participants with low-volume, Gleason score 5 to 6 prostate cancer, who chose to be followed with active surveillance, were enrolled and randomly allocated to receive once-daily dutasteride (144 men) or matching placebo (145 men). The time to prostate cancer progression was the primary end point.

The researchers found that, by three years, significantly fewer men in the dutasteride group (38 percent) had pathologic or therapeutic prostate cancer progression compared with those in the control group (48 percent) (hazard ratio, 0.62; 95 percent confidence interval, 0.43 to 0.89). Adverse event incidence was similar between the groups. Sexual adverse events, breast enlargement, or breast tenderness were seen in 24 percent of the dutasteride group and 15 percent of controls, and 5 percent in each group had cardiovascular adverse events. No prostate cancer-related deaths or cases of metastatic disease were observed.

"Findings from our study show that dutasteride could be a beneficial adjunct to active surveillance for men with low-risk prostate cancer, delaying their time to pathological progression and initiation of primary therapy," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including GlaxoSmithKline, which funded the study and manufactures dutasteride.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events