Exposure to Iodinated Contrast Media Affects Thyroid Function

Linked to subsequent development of incident hyperthyroidism, incident overt hypothyroidism

THURSDAY, Jan. 26 (HealthDay News) -- Exposure to iodinated contrast media (ICM), which are frequently used during imaging procedures, is associated with changes in thyroid function, specifically an increased risk of developing incident hyperthyroidism and incident overt hypothyroidism, according to a study published in the Jan. 23 issue of the Archives of Internal Medicine.

Connie M. Rhee, M.D., from Harvard Medical School in Boston, and colleagues conducted a case-control study of patients treated over 20 years who did not have preexisting thyroid conditions. ICM exposure was assessed using claims data for contrast-enhanced computed tomography or cardiac catheterization. Incident hyperthyroid or hypothyroid cases were defined by a change in thyrotropin level from normal (at baseline) to low or high (follow-up measurement). Controls were selected using an incidence density sampling approach and were matched to cases on the basis of age, sex, race/ethnicity, estimated glomerular filtration rate, follow-up thyrotropin measurement date, and interval between baseline and the follow-up thyrotropin measurement date.

The researchers found 178 and 213 incident hyperthyroid and hypothyroid cases, respectively, who were matched to 655 and 779 euthyroid controls. ICM exposure was significantly associated with incident hyperthyroidism (odds ratio [OR] 1.98) but not with incident hypothyroidism (OR 1.58). In secondary analysis, iodinated contrast media exposure was associated with incident overt hyperthyroidism (follow-up thyrotropin level ≤0.1 mIU/L; OR 2.50) and with incident overt hypothyroidism (follow-up thyrotropin level >10 mIU/L; OR 3.05).

"Iodinated contrast media exposure is associated with subsequent development of incident hyperthyroidism and incident overt hypothyroidism," the authors write.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events