Isoflurane Harmful to Mitochondrial Function in Mice

Desflurane may be a safer choice of anesthetic for patients with Alzheimer's disease

FRIDAY, Jan. 27 (HealthDay News) -- Anesthetics isoflurane and desflurane have distinct effects on mitochondrial function and learning and memory, according to an experimental study published online Jan. 19 in the Annals of Neurology.

Yiying Zhang, M.D., of the Massachusetts General Hospital in Charlestown, and colleagues used flow cytometry, confocal microscopy, Western blot analysis, immunocytochemistry, and the fear conditioning test to assess the effects of isoflurane and desflurane on mitochondrial function, cytotoxicity, and learning and memory in mice and mouse cells.

The researchers found that isoflurane, but not desflurane, was associated with induction of the opening of mitochondrial permeability transition pores (mPTP), elevation of reaction oxygen species levels, decreases in levels of adenosine-5'-triphosphate and mitochondrial membrane potential, and caspase-3 activation. In addition, isoflurane, but not desflurane, impaired learning and memory in cultured cells, mouse hippocampus neurons, mouse hippocampus, and mice. Isoflurane-induced mPTP opening, caspase-3 activation, and impairment of learning and memory were reduced by cyclosporine A, a blocker of mPTP opening.

"Ultimately, these studies, through combined efforts of anesthesia and neurology, may develop guidelines in regards to how to provide safer anesthesia care for Alzheimer's disease patients (e.g., to avoid worsening of Alzheimer's disease neuropathogenesis and decline of cognitive function by anesthesia and surgery), like the one developed by combined efforts of anesthesia and cardiology regarding safer anesthesia care for coronary artery disease patients," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events