Insulin Secretion Impaired in the Insulin-Resistant

Impaired glucose-stimulated insulin secretion in type 2 diabetes, impaired glucose tolerance

WEDNESDAY, Feb. 1 (HealthDay News) -- Individuals with impaired glucose tolerance or type 2 diabetes have impaired glucose-stimulated insulin secretion after exposure to insulin compared with healthy individuals, according to a study published in the February issue of Diabetes.

Florencia Halperin, M.D., from the Joslin Diabetes Center in Boston, and colleagues investigated how pre-exposure to insulin affected glucose-stimulated insulin secretion in 10 individuals with impaired glucose tolerance, 11 patients with type 2 diabetes, and eight healthy individuals. Following a four-hour clamp with sham (saline infusion) or an isoglycemic-hyperinsulinemic clamp using B28-Asp-insulin (which raised insulin concentrations to high physiologic concentrations), dextrose was administered for 80 minutes to assess the insulin secretory response.

The researchers found that pre-exposure to insulin increased glucose-stimulated insulin secretion in healthy individuals. In patients with impaired glucose tolerance and those with type 2 diabetes, the effect was reduced.

"In conclusion, we have demonstrated that while the β-cell is insulin responsive and pre-exposure to insulin enhances glucose-stimulated insulin secretion in healthy humans, this effect is reduced in states of insulin resistance," Halperin and colleagues write. "Thus we demonstrate physiologically that the β-cell is an insulin-responsive tissue in humans in vivo."

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events