AHA: Rivaroxaban Tied to Lower Brain Bleed Risk in A-Fib

Compared to warfarin, rivaroxaban offers less risk of intracranial hemorrhage in a-fib patients

THURSDAY, Feb. 2 (HealthDay News) -- A once daily oral dose of rivaroxaban (Xarelto) significantly lowers the risk of intracranial hemorrhage (ICH) in patients with atrial fibrillation (AF) at moderate to high risk of stroke, according to a study presented at the American Heart Association's International Stroke Conference, held from Feb. 1 to 3 in New Orleans.

Graeme J. Hankey, M.B.B.S., M.D., of the Royal Perth Hospital in Australia, and colleagues studied 14,264 patients with nonvalvular AF randomized to rivaroxaban or dose-adjusted warfarin. Participants were followed for a median of 1.94 years.

The researchers found that, over the study period, 136 patients experienced ICH events (intracerebral hemorrhage [98], subarachnoid hemorrhage [5], subdural hemorrhage [32], and extradural hemorrhage [1]), with an average annual rate of 0.55 per 100 patient-years. Increased age, previous stroke or transient ischemic attack, black or Asian race, decreasing serum albumin, and decreased platelet count below 210 × 109/l were identified as significant, independent predictors of increased risk for ICH. Adjusting for other variables, creatinine clearance was not associated with the occurrence of ICH (P = 0.3181). Aspirin and thienopyridine use at baseline correlated with an increased risk of ICH, while rivaroxaban was protective compared to warfarin.

"Rivaroxaban was associated with a significantly lower risk of ICH compared with warfarin," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Johnson & Johnson and Bayer HealthCare, which funded the study and jointly developed rivaroxaban.

Abstract No. 152
More Information

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events