Vitamin D Not Linked to Insulin Sensitivity in Teens

Plasma 25(OH)D concentration not tied to glucose homeostasis, insulin sensitivity, β-cell function

FRIDAY, Feb. 10 (HealthDay News) -- Vitamin D concentrations have no independent association with insulin sensitivity or β-cell function in black and white youth, according to a study published online Jan. 11 in Diabetes Care.

Kumaravel Rajakumar, M.D., of the University of Pittsburgh School of Medicine, and associates analyzed plasma 25-hydroxyvitamin D (25[OH]D) concentrations and β-cell function to determine their relationship with insulin sensitivity and disposition index (DI) in 183 healthy black and white youth aged 8 to 18 years.

The researchers found that, for whites, there were no differences in hemoglobin A1c, fasting glucose and insulin, insulin sensitivity, or DI across quartiles of plasma 25(OH)D. In the highest quartile of 25(OH)D there was significantly higher insulin sensitivity and DI for blacks, but this disappeared after adjusting for adiposity measures. When adjusting for adiposity, the difference in insulin sensitivity between nondeficient and deficient black youth also disappeared.

"In conclusion, our data show no independent relationship between plasma 25(OH)D and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in otherwise healthy black and white youth," the authors write. "It remains to be determined whether similar or different relationships will be found in youth with dysglycemia and whether vitamin D optimization in vitamin D-deficient youth will enhance insulin sensitivity and β-cell function."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Abdominal Pain: An Approach to a Challenging Diagnosis
AACN Advanced Critical Care, July/September 2014
Free access will expire on October 13, 2014.


HIPAA Compliance Practice Tips
Professional Case Management, July/August 2014
Free access will expire on September 29, 2014.


Follow the leader: How does “followership” influence nurse burnout?
Nursing Management, August 2014
Free access will expire on September 29, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events