Digital Colposcopy Enhances Cervical Cancer Detection

DSI colposcopy more sensitive for HPV16+ than for non-16 high-risk HPV+ women

TUESDAY, Feb. 14 (HealthDay News) -- Dynamic spectral imaging (DSI) colposcopy is more sensitive for detecting cervical intraepithelial neoplasia (CIN2+) in women who are human papillomavirus type 16-positive (HPV16+) than for women who are non-16 high-risk (hr) HPV+, according to a study published online Feb. 3 in BJOG: An International Journal of Obstetrics and Gynaecology.

Afra Zaal, M.D., of the University Medical Center Utrecht in the Netherlands, and associates conducted a prospective clinical trial involving 177 adult women (age 18 years or older) with an intact cervix, referred for colposcopy at three clinics, to investigate the agreement between conventional colposcopic impression, DSI colposcopy, and histology. Lesions were graded using the DSI colposcope as a regular video colposcope. HPV typing was performed with a cervical smear.

The researchers found that DSI digital colposcopy identified more CIN2+ lesions in HPV16+ women than in non-16 hrHPV+ women (P = 0.032 regardless of final histology and P = 0.009 among women with CIN2+). Data showed that the sensitivity of DSI colposcopy to detect CIN2+ lesions was 97 percent in HPV16+ women, compared with 74 percent in non-16 hrHPV+ women (P = 0.009). These differences were not seen for the colposcopist impression. The colposcopist mainly missed smaller cervical lesions.

"The sensitivity of DSI colposcopy for CIN2+ is higher in HPV16+ than in non-16 hrHPV+ women," the authors write. "Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2+ is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions."

Several authors disclosed financial ties to DySIS Medical Ltd., which partially funded the study and provided the DSI digital colposcope used in the study.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Dogs as Pets, Visitors, Therapists and Assistants
Home Healthcare Nurse, November/December 2014
Free access will expire on January 5, 2015.


Tracheostomy Care
Nursing2014 Critical Care, November 2014
Free access will expire on December 22, 2014.


Effective management of ARDS
The Nurse Practitioner, 13December 2014
Free access will expire on December 22, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events