Cancer Risk Higher in Children With Juvenile Arthritis

Treatment with methotrexate, TNF inhibitors have no effect on risk

MONDAY, Feb. 13 (HealthDay News) -- Children with juvenile idiopathic arthritis (JIA) are significantly more likely to develop cancer than children without the condition, although common treatments have no effect on risk, according to a study published online Feb. 10 in Arthritis & Rheumatism.

Timothy Beukelman, M.D., from the University of Alabama at Birmingham, and colleagues compared relative rates of incident malignancy in 7,812 children with JIA, 652,234 children with asthma, and 321,821 children with attention-deficit/hyperactivity disorder (ADHD). Children with JIA were categorized according to treatment with methotrexate and tumor necrosis factor (TNF) inhibitors, as ever or never exposed. Incident malignancies were classified as possible, probable, or highly probable. Standardized incidence ratios (SIRs) were assessed using the 321,821 children with ADHD as a reference group.

The researchers found that, for probable and highly-probable malignancies, the SIR for children with JIA was 4.4 (95 percent confidence interval [CI], 1.8 to 9.0). The SIR was 3.9 (95 percent CI, 0.4 to 14) for methotrexate users without TNF inhibitor use, and the SIR was zero (95 percent CI, 0 to 9.7) following the use of any TNF inhibitors.

"Children with JIA appeared to have an increased rate of incident malignancy compared to children without JIA," Beukelman and colleagues conclude. "JIA treatment, including TNF inhibitors, did not appear significantly associated with the development of malignancy."

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events