Smoking Cessation Drug May Also Reduce Drinking

Varenicline increases alcohol's aversive effects, including dysphoria and nausea

FRIDAY, Feb. 17 (HealthDay News) -- The smoking cessation drug varenicline (VAR) may also reduce alcohol consumption in social drinkers by increasing alcohol's aversive effects, according to a study published online Feb. 16 in Alcoholism: Clinical & Experimental Research.

Emma Childs, Ph.D., of the University of Chicago, and colleagues investigated the effects of an acute dose of VAR upon subjective, psychological, and objective responses to alcohol in 15 healthy social drinkers. The drinkers participated in six randomized sessions: three each with 2-mg VAR and placebo, followed three hours later by a drink containing placebo, low-dose alcohol (0.4 g/kg), or high-dose alcohol (0.8 g/kg). Subjective mood and drug effects (stimulation, drug liking), physiological measures (heart rate, blood pressure), and eye tracking tasks were assessed periodically before and after drug and alcohol administration.

The researchers found that blood pressure, heart rate, ratings of dysphoria, and nausea were acutely increased by VAR, and it also improved eye tracking performance. After drinking alcohol, VAR increased dysphoria and tended to reduce alcohol liking ratings, while attenuating alcohol-induced eye-tracking impairments, compared with placebo. These findings were independent of the drug's effects on nausea before drinking.

"VAR may reduce alcohol drinking behaviors among light smokers by increasing the negative subjective effects of a low dose of alcohol, thus reducing the likelihood of a drinking episode becoming a binge," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events