High Levels of Genital HLA-G Linked With HIV-1 Infection

Increased expression of soluble HLA-G in genital mucosa tied to HIV-1 infection, bacterial vaginosis

THURSDAY, Feb. 16 (HealthDay News) -- High genital levels of soluble HLA-G (sHLA-G), a powerful modulator of the immune response, are associated with HIV-1 infection in Beninese commercial sex workers (CSWs), according to a study published online in PLoS One.

To investigate whether sHLA-G expression in the female genital tract is associated with HIV-1 infection, Valérie Thibodeau, of the University of Montreal, and colleagues determined genital levels of sHLA-G in 52 HIV-1-uninfected female CSWs, 44 antiretroviral naive HIV-1-infected female CSWs, and 71 HIV-1-uninfected non-CSW women at low risk of exposure.

The researchers found that HIV-1-infected CSWs had significantly higher genital levels of sHLA-G compared with those in the HIV-1-uninfected CSW and non-CSW groups (P = 0.009 and 0.0006, respectively). In the HIV-1 infected CSWs, the presence of bacterial vaginosis and HLA-G*01:01:02 genotype were associated with higher genital levels of sHLA-G (P = 0.008 and 0.002, respectively). In the overall population, HLA-G*01:04:04 genotype correlated with higher genital levels of sHLA-G (P = 0.038). The increased expression of sHLA-G in the genital mucosa remained significantly associated with both HIV-1 infection (P = 0.02) and bacterial vaginosis (P = 0.03), even after adjusting for all relevant variables.

"This study demonstrates that high levels of sHLA-G in the genital mucosa is independently associated with both HIV-1 infection and bacterial vaginosis," the authors write.

Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events