C-Peptide Still Produced After Decades of Diabetes

C-peptide responsive to hyperglycemia, suggesting residual β-cell function

WEDNESDAY, Feb. 22 (HealthDay News) -- Some patients who have had type 1 diabetes for decades can still produce C-peptide and respond to hyperglycemia, suggesting residual β-cell function, according to a study published in the March issue of Diabetes Care.

Limei Wang, Ph.D., from Massachusetts General Hospital in Boston, and colleagues used an ultrasensitive assay (lower detection limit, 1.5 pmol/L; 22 times more sensitive than standard assays), to measure the serum levels of C-peptide, a marker of insulin production, in 182 patients with type 1 diabetes.

The researchers found that C-peptide levels declined with longer durations of disease, with C-peptide detected in 10 percent of patients 31 to 40 years after disease onset. However, patients who developed diabetes after 40 had low levels of C-peptide, in spite of short disease duration. Increased C-peptide production was seen in response to hyperglycemia, even in those with levels as low as 2.8 ± 1.1 pmol/L. Several analyses indicated that β-cells were able to function. Disease duration and level of zinc transporter 8 autoantibodies correlated significantly with C-peptide production.

"The ultrasensitive assay revealed that C-peptide production persists for decades after disease onset and remains functionally responsive," Wang and colleagues conclude. "These findings suggest that patients with advanced disease, whose β-cell function was thought to have long ceased, may benefit from interventions to preserve β-cell function or to prevent complications."

Abstract
Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events