Prevalence of Screening for Lynch Syndrome Varies

Genetic screening for Lynch syndrome less common at community hospitals

THURSDAY, Feb. 23 (HealthDay News) -- Screening for Lynch syndrome, the most common form of inherited colorectal cancer, after a colorectal cancer diagnosis is common at comprehensive cancer centers but not community hospitals, according to a study published online Feb. 21 in the Journal of Clinical Oncology.

To describe prevalent practices regarding immunohistochemistry (IHC) and microsatellite instability (MSI) reflex testing for Lynch syndrome after a colorectal cancer diagnosis, Laura C. Beamer, Ph.D., from City of Hope in Duarte, Calif., and colleagues surveyed 39 National Cancer Institute-designated Comprehensive Cancer Centers (NCI-CCCs), 50 American College of Surgeons-accredited Community Hospital Comprehensive Cancer Programs (COMPs), and 50 Community Hospital Cancer Programs (CHCPs). The overall response rate for all centers and programs was 50 percent.

The researchers found that reflex testing was conducted by 71 percent of NCI-CCCs, 36 percent of COMPs, and 15 percent of CHCPs. Of these, 48 percent used IHC, 14 percent used MSI, and 38 percent used both. None of the institutions required written consent, one used a presurgical information packet, and four offered an opt-out option.

"Although most NCI-CCCs use reflex IHC/MSI to screen for Lynch syndrome, this practice is not well-adopted by community hospitals," Beamer and colleagues conclude. "These findings may indicate an emerging standard of care and diffusion from NCI-CCCs to community cancer programs."

Abstract
Full Text (subscription or payment may be required)
Editorial

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events