View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
TUESDAY, Feb. 21 (HealthDay News) -- Brain insulin may act as a satiety signal during the postprandial period and is associated with decreased appetite and reduced intake of highly palatable food, according to a study published online Feb. 16 in Diabetes.
Manfred Hallschmid, Ph.D., from the University of Lübeck in Germany, and colleagues investigated the role of brain insulin signaling in the control of food intake. In two groups of healthy women, 160 IU insulin or vehicle were administered after lunch, and two hours later, the consumption of cookies of varying palatability was evaluated under the pretext of a taste test. Intranasal insulin was administered to fasted females as a control study.
The researchers found that, compared with placebo, insulin administration in the postprandial state, but not in the fasted state, decreased appetite along with intake and rated palatability of the most palatable snack offered. Intranasal insulin administration was associated with a small decrease in plasma glucose, but no effect on serum insulin concentration was seen.
"Postprandially administered intranasal insulin enhances the satiating effect of meals and reduces palatable snack intake, suggesting that insulin acts as a relevant signal in the short-term regulation of satiety in humans," the authors write. "Considering that the rewarding effect of palatable food overriding the homeostatic control of energy intake may promote obesity, insulin's potential to curb the appetite for hedonically salient, calorie-rich food deserves particular attention."
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top