Skin Cancer Frequency in Chronic Leg Ulcers >10 Percent

Frequency high enough to consider systematic wound biopsy for treatment-refractory ulcers

WEDNESDAY, Feb. 22 (HealthDay News) -- Chronic leg ulcers (CLUs) that don't heal after three months of appropriate treatment have an overall skin cancer frequency of 10.4 percent, according to a study published online Feb. 20 in the Archives of Dermatology.

To investigate the frequency of skin cancers associated with CLUs, Patricia Senet, M.D., of Université Paris X, and colleagues studied 144 ambulatory or hospitalized patients with 154 CLUs attributed to venous and/or peripheral arterial disease(s), with increasing wound size (area and/or depth), despite receiving appropriate standard treatment for at least three months. Upon inclusion in the study, at least two 6-mm punch biopsies (one at the wound edge and one in the wound bed) were systematically performed.

The researchers found that the overall frequency of skin cancer in the CLUs was 10.4 percent; with nine squamous cell carcinomas, five basal cell carcinomas, one melanoma, and one leiomyosarcoma. More than half (56.3 percent) had persisted for at least three years. Older age, abnormal excessive granulation tissue at the wound edges, high clinical suspicion of cancer, and number of biopsies were significantly associated with skin cancer on univariate analysis. Neither wound area or duration, were significantly associated with skin cancer.

"The combined primary ulcerated cancer or malignant transformation frequency was sufficiently high in CLUs referred to tertiary care centers to consider systematic biopsy of a wound refractory to three months or more of appropriate treatment," write the authors.

Several authors disclosed financial ties to Urgo Medical, which partially funded the study.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Abdominal Pain: An Approach to a Challenging Diagnosis
AACN Advanced Critical Care, July/September 2014
Free access will expire on October 13, 2014.


HIPAA Compliance Practice Tips
Professional Case Management, July/August 2014
Free access will expire on September 29, 2014.


Follow the leader: How does “followership” influence nurse burnout?
Nursing Management, August 2014
Free access will expire on September 29, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events