Family History Ups Risk of Differentiated Thyroid Cancer

Patients with first-degree relative, especially sibling, with thyroid cancer have elevated risk

THURSDAY, Feb. 23 (HealthDay News) -- Family history of thyroid cancer in a first-degree relative may be associated with an increased risk of sporadic differentiated thyroid carcinoma (DTC), according to a study published in the March 1 issue of Cancer.

Li Xu, Ph.D., from the University of Texas M.D. Anderson Cancer Center in Houston, and colleagues investigated the correlation between sporadic DTC and family history of cancer in a hospital-based study. A questionnaire was completed by 288 patients with sporadic DTC, and 591 cancer-free controls, to estimate the DTC risk.

The researchers found that family history of thyroid cancer in a first-degree relative correlated with an elevated DTC risk (adjusted odds ratio [OR], 4.1). In patients with a first-degree relative with thyroid cancer, all DTC cases were papillary thyroid carcinoma (PTC; adjusted OR, 4.6). In individuals with a family history of thyroid cancer among siblings, the risk of PTC was highest (OR, 7.4). Among PTC patients with first-degree family history of thyroid cancer, multifocal primary tumor was more common than in those with no first-degree family history (68.8 versus 35.5 percent; P = 0.01).

"Here we provide evidence suggesting that family history of thyroid cancer in first-degree relatives is associated with a significant increase in sporadic PTC risk and that risk is greater for people whose siblings were diagnosed with thyroid cancer. Such results should be interpreted with caution, and confirmation by larger prospective studies is warranted," the authors write.

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95

Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95

Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events