Secondhand Smoke Shortens Transplant Survival in Mice

Research unveils novel immunologic mechanism behind smoke-related allograft rejection

THURSDAY, March 1 (HealthDay News) -- The immunologic mechanisms behind smoke-related graft rejection have been elucidated, according to a study published in the March issue of the American Journal of Transplantation.

F. Wan, of the University of Texas Health Science Center in Tyler, and colleagues used mouse transplant models to investigate the impact of exposure to smoke on transplant survival and its mechanism of action.

The researchers found that secondhand smoke (SHS) impaired long-term islet allograft survival induced by CD154 costimulatory blockade plus donor-specific splenocyte transfusion (DST). SHS did not alter acute islet allograft rejection, nor did it directly interfere with vigorously alloreactive T-cell proliferation in vivo and in vitro. SHS did not cause a significant reduction in either naturally occurring or induced CD4+CD25+ regulatory T cell numbers. However, SHS suppressed mRNA and protein expression of indoleamine 2, 3-dioxygenase (IDO) and its activity upon transplantation. Overexpression of IDO in islet allografts restored their long-term survival induced by CD154 blockade.

"Our study for the first time demonstrates that SHS shortens allograft survival in a cause-effect manner and unveils a novel immunologic mechanism underlying smoking-related allograft rejection," the authors write.

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events