Thalidomide Induces Complete Response in Cutaneous Lupus

Low-dose thalidomide induces complete, sustained response for majority with refractory CLE

THURSDAY, March 1 (HealthDay News) -- Low-dose thalidomide successfully induces complete response in a majority of patients with refractory cutaneous lupus erythematosus (CLE), according to research published in the March issue of the British Journal of Dermatology.

To evaluate the clinical efficacy and safety of thalidomide and establish prognostic factors of clinical outcome, J. Cortés-Hernández, M.D., of the Universitat Autònoma de Barcelona in Spain, and colleagues conducted a prospective observational study involving 60 consecutive patients with refractory CLE who were treated with 100 mg per day of thalidomide. The treatment was completed by all patients except one who discontinued due to side effects.

During the eight-year follow-up period, the researchers found that 98 percent of subjects achieved a clinical response, which was noticeable at two weeks after treatment. Eighty-five percent of patients experienced a complete response. Clinical relapse occurred for 70 percent of patients, usually five months after withdrawal or reduction of treatment. Subjects with subacute CLE were 30 times more likely to achieve long-term remission after treatment discontinuation (odds ratio, 30), while those with discoid lupus erythematosus were significantly more likely to relapse with treatment discontinuation (odds ratio, 5.71). Neurological symptoms associated with thalidomide treatment included paraesthesia (18 percent), which was confirmed as sensory polyneuropathy in five of eleven patients. Symptoms resolved 12 months after treatment withdrawal.

"Thalidomide has proven to be effective in patients with refractory CLE," the authors write. "Based on these results, low-dose thalidomide should be given prime consideration in the treatment of antimalarial drug-resistant CLE, but always under careful clinical surveillance."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events