View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
WEDNESDAY, Feb. 29 (HealthDay News) -- The addition of nicotine-replacement therapy to behavioral cessation support does not increase the rate of smoking abstinence in pregnant women, according to a study published in the March 1 issue of the New England Journal of Medicine.
Tim Coleman, M.D., of the University of Nottingham in the United Kingdom, and colleagues studied 1,050 women (aged 16 to 50 years) with pregnancies of 12 to 24 weeks' gestation and who smoked five or more cigarettes per day. Participants received behavioral cessation support and were randomly assigned to eight weeks of treatment with active nicotine patches (15 mg per 16 hours) or matched placebo patches. Safety assessment included monitoring for adverse pregnancy and birth outcomes.
The researchers found no significant difference in the rate of abstinence from the quit date until delivery between the nicotine-replacement and placebo groups (9.4 and 7.6 percent, respectively; unadjusted odds ratio with nicotine-replacement therapy, 1.26; 95 percent confidence interval, 0.82 to 1.96). At one month, the rate of abstinence was higher in the nicotine-replacement group than in the placebo group (21.3 versus 11.7 percent). Compliance was low, with only 7.2 percent of the nicotine-replacement group and 2.8 percent of the placebo group using patches for more than one month. Rates of adverse pregnancy and birth outcomes were similar between the groups.
"Adding a nicotine patch (15 mg per 16 hours) to behavioral cessation support for women who smoked during pregnancy did not significantly increase the rate of abstinence from smoking until delivery or the risk of adverse pregnancy or birth outcomes," the authors write.
The author of the editorial disclosed financial ties the biopharmaceutical industry.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top