View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
TUESDAY, Feb. 28 (HealthDay News) -- Even relatively small doses of sleeping pills are associated with a more than three-fold higher risk of death, according to a study published online Feb. 27 in BMJ Open.
Daniel F. Kripke, M.D., from the Scripps Clinic Viterbi Family Sleep Center in La Jolla, Calif., and colleagues analyzed data on mortality from 10,529 patients who were prescribed a range of sleeping pills, and 23,676 matched controls who did not take sleeping pills. Subjects were an average of 54 years old.
After an average of 2.5 years, and after adjusting for a possible confounding factors, the researchers found that the risk of death increased with increasing doses of drug. The hazard ratios were 3.60 for 0.4 to 18 doses a year, 4.43 for 18 to 132 doses a year, and 5.32 for >132 doses a year. The highest dose was also associated with an increased risk of cancer (hazard ratio, 1.35).
"Receiving hypnotic prescriptions was associated with greater than three-fold increased hazards of death even when prescribed <18 pills/year," Kripke and colleagues conclude. "This association held in separate analyses for several commonly used hypnotics and for newer shorter-acting drugs."
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top