Epigenetic Blockade May Impair Cognition in Alzheimer's

Histone deacetylase 2 reduces histone acetylation of genes involved in learning, memory in mice

THURSDAY, March 1 (HealthDay News) -- An epigenetic blockade may be responsible for cognitive impairment in Alzheimer's disease, and reversing this blockade improves cognitive abilities in mouse models of Alzheimer-like neurodegeneration, according to an experimental study published online Feb. 29 in Nature.

Noting that reduced histone acetylation has been associated with cognitive decline, and that histone deacetylase 2 (HDAC2) is known to negatively regulate memory in healthy mice, Johannes Gräff, Ph.D., from the Massachusetts Institute of Technology in Cambridge, and colleagues investigated whether HDAC2 mediates cognitive deficits associated with neurodegeneration in a mouse model of Alzheimer's disease.

The researchers found that HDAC2 was significantly elevated in the hippocampi in mouse models of Alzheimer-like neurodegeneration, by Alzheimer's-disease-related neurotoxic insults in vitro, and in patients with Alzheimer's disease. HDAC2 reduced histone acetylation of genes important for learning and memory, decreasing their expression. Short-hairpin-RNA-mediated knockdown reversed this reduction, restored structural and synaptic plasticity, and abolished the memory impairments.

"These findings advocate for the development of selective inhibitors of histone deacetylase 2 and suggest that cognitive capacities following neurodegeneration are not entirely lost, but merely impaired by this epigenetic blockade," Gräff and colleagues conclude.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events