View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, March 5 (HealthDay News) -- For children with asthma, an increased body mass index (BMI) is associated with a decreased response to corticosteroids (CS) and increased daily requirements for inhaled CS (ICS), according to a study presented at the annual meeting of the American Academy of Allergy, Asthma & Immunology, held from March 2 to 6 in Orlando, Fla.
To investigate whether BMI affects the CS response in children with asthma, Rolando A. Nunez, M.D., from National Jewish Health in Denver, and colleagues studied peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage (BAL) cells from 61 children with asthma, aged 2 to 18 years, who underwent clinically indicated bronchoscopies.
The researchers found that 34 children had normal weight, 13 were overweight, and 14 were obese. Fifty-six participants used ICS. BMI percent correlated significantly with plasma leptin (P = 0.0001), daily ICS dose (P = 0.0035), and dexamethasone-induced mitogen-activated protein kinase phosphatase-1 (MKP-1) in PBMC and BAL cells (P = 0.0009 and 0.0205, respectively). There was a negative association between MKP-1 induction and the daily requirement of ICS (P = 0.0303).
"Chronic inflammation, as seen in obese patients, is thought to interfere with the body's response to corticosteroids, leading to a higher corticosteroid requirement in patients with asthma," a co-author said in a statement. "More studies are needed to find out if the response to the medication might improve if obese children with asthma lose weight."
Abstract No. 482
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top