Increase especially high for African-Americans; often due to adverse effects of ACE inhibitors
TUESDAY, March 6 (HealthDay News) -- The rate of angioedema hospitalization has increased over the last decade, especially among African-Americans, according to a study presented at the annual meeting of the American Academy of Allergy, Asthma & Immunology, held from March 2 to 6 in Orlando, Fla.
Robert Y. Lin, M.D., of the New York Downtown Hospital in New York City, and R.J. Levine, of New York Medical College in Valhalla, queried a U.S. national hospitalization database for admissions due to angioedema and other allergic disorders to investigate angioedema hospitalization trends from 2000 to 2009. Clinical and demographic associations with these trends were assessed.
The researchers found that the rate of angioedema hospitalization rose from 2.7/105 in 2000 to 4.2/105 in 2009. During the same period, the hospitalization rate for other allergic disorders was stable at 1.5/105. The proportion of African-Americans increased from 32 percent of angioedema admissions in 2000 to 41 percent of admissions in 2009. Adverse drug effects due to cardiovascular/hypertension agents correlated strongly with angioedema, and increased from 22 percent in 2000 to 36 percent in 2009. Adverse drug effects were seen in 38 percent of African-American patients and 25 percent of patients of other races who were hospitalized for angioedema.
"Angioedema hospitalization rates have continued to rise from 2000 to 2009 in the United States, especially in the African-American population. Hospitalization rates of angioedema continue to exceed hospitalization rates of other acute allergic reactions," the authors write.
Abstract No. 834