View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
THURSDAY, March 29 (HealthDay News) -- Patients with rheumatoid arthritis are at higher risk of death from cardiovascular and non-cardiovascular causes if they discontinue statin treatment, according to a study published online March 29 in Arthritis Care & Research.
Mary A. De Vera, Ph.D., from the Arthritis Research Centre of Canada in Vancouver, and colleagues analyzed data from 4,102 rheumatoid arthritis patients taking statins between 1996 and 2006. About 45 percent of patients discontinued statin treatment, defined by at least three months of persistent non-use at least once during study follow-up.
Over a follow-up of 16,144 person-years, the researchers identified 467 deaths, of which 198 were due to cardiovascular disease. After adjusting for possible confounding factors, they found that the hazard ratio for statin discontinuation and death was 1.60 for cardiovascular mortality and 1.79 for all-cause mortality. Age, sex, and timing of first statin prescription had no significant effect on the association.
"These population-based data indicate that statin discontinuation in rheumatoid arthritis patients is associated with increased risk of death from cardiovascular disease and all causes," De Vera and colleagues conclude. "Findings provide support for the importance of compliance with therapy in rheumatoid arthritis patients who are prescribed statins."
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top