View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, April 9 (HealthDay News) -- For men with type 2 diabetes treated with metformin, prostate cancer (PCa) incidence varies depending on statin use, with a significantly reduced risk for patients taking a combination of metformin and statins, according to a study published online March 28 in Diabetes Care.
Donna M. Lehman, Ph.D., from the University of Texas Health Science Center in San Antonio, and colleagues analyzed data from 5,042 men with type 2 diabetes treated in the Veteran Administration Health Care System. Participants had no history of prior cancer and were treated exclusively with metformin or sulfonylurea as a hypoglycemic medication between 1999 and 2005.
During a mean follow-up of five years, the researchers found that 7.5 percent of men had a PCa diagnosis. Metformin correlated with a significantly lower PCa incidence among patients on statins (hazard ratio [HR], 0.69; 17 cases in 533 metformin users versus 135 cases in 2,404 sulfonylureas users) and an elevated PCa incidence among patients not on statins (HR, 2.15; 22 cases in 175 metformin users versus 186 cases in 1,930 sulfonylureas users). When compared with those patients taking neither medication, patients treated with metformin and statins had a PCa incidence HR of 0.32.
"Among men with type 2 diabetes, PCa incidence among metformin users varied by their statin use," the authors write. "The potential beneficial influence on PCa by combination use of metformin and statin may be due to synergistic effects."
Full Text (subscription or payment may be required)
Find in-depth content on major issues provided by leading companies in partnership with NursingCenter.com
BD Safety Beyond Needlestick Prevention Learning Center
Sponsored by BD Medical
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top