Prenatal Antipsychotics Impact Infant Neuromotor Function

Exposure to antipsychotics adversely affects neuromotor function in 6-month-old infants

THURSDAY, April 5 (HealthDay News) -- The use of prescribed antipsychotics during pregnancy may result in significantly lower neuromotor performance in 6-month-old infants, according to a study published online April 2 in the Archives of General Psychiatry.

To investigate whether intrauterine antipsychotic exposure correlated with deficits in neuromotor performance and habituation, Katrina C. Johnson, Ph.D., of Emory University in Atlanta, and colleagues conducted a prospective controlled study of 309 maternal-infant dyads at six months postpartum. Infants had been exposed to antipsychotics (22 infants), antidepressants (202 infants), or had no psychotropic exposure (85 infants). The Infant Neurological International Battery (INFANIB) exam was used to test posture, tone, reflexes, and motor skills. Habituation was assessed using a visual paradigm with a neutral female face.

The researchers found that, after controlling for confounding variables, INFANIB scores were significantly lower for infants exposed to antipsychotics than for those exposed to antidepressants or not exposed. Data showed that maternal psychiatric history, including depression, psychosis, and overall severity/chronicity were significantly associated with INFANIB scores (P's < 0.05). Maternal depression during pregnancy was correlated with less efficient habituation (P < 0.02). With respect to habituation, no significant differences were seen for the different medication groups.

"These data support an additional level of clinical scrutiny in medication selection, treatment planning, and risk/benefit discussions for women with illnesses who may warrant antipsychotic pharmacotherapy during gestation," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events