Endodermal Progenitor Cells Generate Into Multiple Cell Types

Derived from embryonic and induced pluripotent stem cells, endodermal progenitor cells are not tumorigenic

FRIDAY, April 6 (HealthDay News) -- Endodermal progenitor (EP) cells derived from embryonic stem cells and induced pluripotent stem cells can differentiate into multiple cell types, including functional pancreatic β-cells, and are not tumorigenic, according to a study published in the April 6 issue of Cell Stem Cell.

Noting that pluripotent stem cells can form tumors and fail to form pure populations of differentiated cell types, Xin Cheng, Ph.D., from the Children's Hospital of Philadelphia, and colleagues manipulated embryonic stem cells and induced pluripotent stem cells into becoming EP cells in vitro using cytokines.

The researchers established optimized growth conditions which allowed almost unlimited EP cell self-renewal. The EPs cells displayed morphology and gene expression patterns which were characteristic of endoderm. The EP cells could differentiate into multiple endoderm-derived cell types, including hepatocytes, intestinal epithelia, and pancreatic β-cells, after manipulation of culture conditions in vitro or after transplantation into mice. The pancreatic β-cells released insulin in response to glucose. The EP cells were not tumorigenic in mice.

"Thus, EP cells represent a powerful tool to study endoderm specification and offer a potentially safe source of endodermal-derived tissues for transplantation therapies," Cheng and colleagues conclude.

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events