Immunotherapy Tied to Lower Alzheimer's CSF Biomarkers

Anti-β-amyloid monoclonal antibody, bapineuzumab, linked to decreases in T-tau, P-tau

FRIDAY, April 6 (HealthDay News) -- For patients with mild-to-moderate Alzheimer's disease, immunotherapy treatment with the anti-β-amyloid (Aβ) monoclonal antibody bapineuzumab results in lower concentrations of two cerebrospinal fluid (CSF) biomarkers: total (T)-tau and phosphorylated (P)-tau, according to a study published online April 2 in the Archives of Neurology.

Kaj Blennow, M.D., Ph.D., of the University of Gothenburg in Mölndal, Sweden, and colleagues conducted two 12-month multicenter, randomized, double-blind, placebo-controlled trials involving 46 patients with mild-to-moderate Alzheimer's disease to determine whether bapineuzumab has an effect on CSF biomarkers.

At the end of the study, the researchers found that bapineuzumab-treated patients had reduced levels of the CSF biomarkers T-tau and P-tau compared with baseline. The observed differences between bapineuzumab- and placebo-treated patients were statistically significant for P-tau (P = 0.03), and there was a trend toward significance for T-tau (P = 0.09). The differences for CSF Aβ were not clear cut.

"To our knowledge, this study is the first to show that passive Aβ immunotherapy with bapineuzumab results in decreases in CSF T-tau and P-tau, which may indicate downstream effects on the degenerative process," the authors write. "Cerebrospinal fluid biomarkers may be useful to monitor the effects of novel disease-modifying anti-Aβ drugs in clinical trials."

The authors disclosed financial ties to pharmaceutical companies, including Elan and Wyeth Pharmaceuticals, which funded the study.

Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events