Herbal Carcinogen Linked to Urothelial Cancer in Taiwan

Carcinogen associated with A:T to T:A transversions in tumor suppressor and oncogenes

FRIDAY, April 13 (HealthDay News) -- A carcinogen produced by Aristolochia plants, which are commonly used in herbal remedies in Taiwan, is associated with signature types of DNA damage linked to aristolochic acid in Taiwanese patients with urothelial carcinoma of the upper urinary tract (UUC), according to a study published online April 9 in the Proceedings of the National Academy of Sciences.

Noting that aristolochic acid is known to be toxic and carcinogenic to the kidney, Chung-Hsin Chen, from the National Taiwan University Hospital in Taipei, and colleagues examined biomarkers associated with UUC in 151 UUC patients and 25 patients with renal cell carcinoma as controls; all patients lived in Taiwan. The authors note that the incidence of UUC in Taiwan is the highest in the world.

The researchers found that patients with UUC had a unique mutational signature in the TP53 tumor suppressor gene, including A:T to T:A transversion, that was identical to the signature found in Balkan endemic nephropathy, which is linked to ingestion of Aristolochia clematitis in wheat. These transversions were also found in the FGFR3 and HRAS oncogenes, in activating positions. Aristolactam-DNA adducts were found in the renal cortex of 83 percent of patients with A:T to T:A mutations in any of these genes.

"We conclude that exposure to aristolochic acid contributes significantly to the incidence of UUC in Taiwan, a finding with significant implications for global public health," Chen and colleagues write.

One author is an employee of Roche Molecular Systems, where the Amplichip p53 test used in this study is being developed.

Abstract
Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Abdominal Pain: An Approach to a Challenging Diagnosis
AACN Advanced Critical Care, July/September 2014
Free access will expire on October 13, 2014.


HIPAA Compliance Practice Tips
Professional Case Management, July/August 2014
Free access will expire on September 29, 2014.


Follow the leader: How does “followership” influence nurse burnout?
Nursing Management, August 2014
Free access will expire on September 29, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events