View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
FRIDAY, April 13 (HealthDay News) -- Men with non-small-cell lung cancer (NSCLC) treated with crizotinib exhibit rapid suppression of total testosterone (T) levels compared with those who do not receive crizotinib treatment, according to research published online April 4 in Cancer.
Andrew J. Weickhardt, M.B.B.S., D.Med.Sci., of the University of Colorado Anschutz Medical Campus in Aurora, and colleagues conducted a studying measuring T levels in 38 men with metastatic NSCLC, of whom 19 received crizotinib and 19 did not.
The researchers found that low total T levels (<241 ng/dL) were seen in 100 percent of crizotinib-treated men versus 32 percent of non-crizotinib-treated men. The mean total T levels were significantly lower in crizotinib-treated versus non-crizotinib-treated men (131 versus 311 ng/dL). Low T levels were seen in one of five patients who had anaplastic lymphoma kinase gene rearrangements and had not yet received crizotinib. Two patients who previously had normal T levels had a rapid decrease in T and in luteinizing and follicle-stimulating hormone levels within 14 to 21 days of treatment initiation.
"In summary, low T levels were documented in all of our male patients with metastatic NSCLC who received crizotinib treatment," the authors write. "Changes appeared to be both rapid and reversible on commencement and cessation of dosing, respectively, confirming a direct causal relation with crizotinib."
Several authors disclosed financial ties to Pfizer, which manufactures crizotinib. Both authors of the accompanying editorial disclosed financial ties to pharmaceutical companies, including Pfizer.
Find in-depth content on major issues provided by leading companies in partnership with NursingCenter.com
BD Safety Beyond Needlestick Prevention Learning Center
Sponsored by BD Medical
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top