Liver Insulin Resistance Correlates With Cardiac Risk

Close association with levels of cholesterol, C-reactive protein, and triglycerides in men

MONDAY, April 16 (HealthDay News) -- Liver insulin resistance (IR) may be a significant indicator of cardiovascular disease (CVD) risk among men, and correlates more closely with risk factors than whole-body insulin sensitivity, according to a study published online April 5 in the Journal of Internal Medicine.

Jagadish Vangipurapu, of the University of Eastern Finland and Kuopio University Hospital, and colleagues conducted a population-based, cross-sectional cohort study involving 8,750 men without diabetes to evaluate the association between CVD risk factors and markers of liver IR and whole-body insulin sensitivity (Matsuda insulin sensitivity index [ISI]).

Compared to Matsuda ISI, the researchers found that liver IR index correlated significantly more closely with total cholesterol, high-sensitivity C-reactive protein, and total triglycerides. In contrast, there was a nominally higher correlation between Matsuda ISI and systolic and diastolic blood pressure. For the majority of CVD risk factors assessed, the variance explained by liver IR index was larger than that explained by Matsuda ISI.

"Liver IR index correlated more strongly than Matsuda ISI with levels of total cholesterol, C-reactive protein, and triglycerides," the authors write. "Therefore, liver IR might be a significant indicator of CVD risk among men."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

What internal motivators drive RNs to pursue a BSN?
Nursing2014 , October 2014
Free access will expire on November 24, 2014.


Breast Cancer Risk Assessment in Primary Care
MCN, The American Journal of Maternal/Child Nursing, September/October 2014
Free access will expire on November 10, 2014.


Nurses spurring innovation
Nursing Management, October 2014
Free access will expire on November 10, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events