Low Gastroprotective Drug Adherence Ups Upper GI Events

Increased risk of events in patients taking coxibs with low adherence to gastroprotective agents

MONDAY, April 16 (HealthDay News) -- For patients taking cyclooxygenase-2 inhibitors (coxibs), low adherence to gastroprotective agents (GPAs) increases the risk of upper gastrointestinal (UGI) complications, according to a study published online April 16 in Arthritis & Rheumatism.

Vera E. Valkhoff, from Erasmus University Medical Centre in Rotterdam, Netherlands, and colleagues conducted a case-control study using data from 14,416 newly started coxib users (aged ≥50 years) from three European databases who simultaneously used GPAs. Cases with UGI events, including bleeding or symptomatic ulcer, were age-, gender-, database-, and calendar date-matched to event-free controls. The Proportion of coxib treatment Days Covered by a GPA prescription (PDC) was used as a measure of adherence to GPAs.

The researchers found that there were 16,442 coxib+GPA episodes, with the majority of patients using coxibs for less than 30 days. During or shortly after these episodes, 74 patients had an UGI event, with an incidence rate of 11.9 per 1,000 coxib user years. Compared with full adherers (PDC, >80 percent), low GPA adherers (PDC, <20 percent) had an increased risk of UGI events (odds ratio [OR], 1.97; 95 percent confidence interval [CI], 0.84 to 4.60). The risk of UGI events increased by 9 percent for every 10 percent decrease in GPA adherence (OR, 1.09; 95 percent CI, 1.00 to 1.18).

"Decreasing GPA adherence among coxib users is associated with an increased risk of UGI events," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including AstraZeneca, which funded the study.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Abdominal Pain: An Approach to a Challenging Diagnosis
AACN Advanced Critical Care, July/September 2014
Free access will expire on October 13, 2014.


HIPAA Compliance Practice Tips
Professional Case Management, July/August 2014
Free access will expire on September 29, 2014.


Follow the leader: How does “followership” influence nurse burnout?
Nursing Management, August 2014
Free access will expire on September 29, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events