Testosterone Ups Exercise Capacity in Heart Failure

Meta-analysis indicates benefit for patients with moderate-to-severe heart failure

TUESDAY, April 17 (HealthDay News) -- Testosterone supplementation is associated with improved exercise capacity in patients with moderate-to-severe heart failure, according to a meta-analysis published online April 17 in Circulation: Heart Failure.

To assess the effects of testosterone supplementation on exercise capacity, Mustafa Toma, M.D., of the University of British Columbia in Vancouver, Canada, and colleagues conducted a meta-analysis of the literature based on four randomized trials involving 198 patients (84 percent men; average age 67 years) with moderate-to-severe heart failure.

The researchers found that, compared with placebo, testosterone therapy was associated with a significant improvement in exercise capacity, including mean increases in the six-minute walk test (54.0 m), incremental shuttle walk test (46.7 m), and peak maximal oxygen consumption (2.70 mL/kg/min). There were no significant adverse cardiovascular events reported.

"Testosterone is a promising therapy to improve exercise capacity in heart failure patients," the authors write. "Adequately powered randomized controlled trials are now required to assess the benefits of testosterone in this high-risk population assessing quality of life, clinical events, and safety."

Two of the authors disclosed receiving funding from Alberta Innovates -- Health Solutions.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

What internal motivators drive RNs to pursue a BSN?
Nursing2014 , October 2014
Free access will expire on November 24, 2014.


Breast Cancer Risk Assessment in Primary Care
MCN, The American Journal of Maternal/Child Nursing, September/October 2014
Free access will expire on November 10, 2014.


Nurses spurring innovation
Nursing Management, October 2014
Free access will expire on November 10, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events