Angiotensin Receptor Blockers Reduce No-Reflow Post-PCI

For patients with acute MI, ARB pretreatment is significant predictor of reduced no-reflow

MONDAY, April 23 (HealthDay News) -- For patients with acute myocardial infarction (AMI), pretreatment with angiotensin receptor blockers (ARBs) is linked with reduced incidence of the no-reflow phenomenon after percutaneous coronary intervention (PCI), according to a study published online April 10 in Cardiovascular Therapeutics.

To investigate the role of early ARB treatment in the development of no-reflow after infarction, Tau Hu, from Xijing Hospital in Xi'an, China, and colleagues followed 276 patients with AMI who underwent successful PCI. No-reflow was evaluated by the Thrombolysis in Myocardial Infarction (TIMI) frame count method using angiographic images collected after PCI and stenting, with a TIMI flow grade <3 indicative of no-reflow.

In the 51 patients receiving chronic ARB before admission, the researchers found a reduced incidence of no-reflow compared to those not receiving ARB treatment (8.7 versus 26.7 percent; P = 0.003). There was no significant difference in the incidence of the no-reflow phenomenon for patients with and without hypertension. ARB pretreatment, but not blood pressure, was a significant predictor of no-reflow.

"Chronic pretreatment of ARB is associated with the reduction of the no-reflow phenomenon in patients with reperfused AMI and could preserve microvascular integrity after AMI independent of blood pressure lowering, which may contribute to better functional recovery," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events