View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, April 23 (HealthDay News) -- Adolescent and young adult patients with acute lymphoblastic leukemia (ALL) who are treated with pediatric-inspired regimens exhibit lower all-cause mortality, higher complete remission and event-free survival rates, and lower relapse rates compared with those treated with conventional adult-chemotherapy regimens, according to a study published in the May issue of the American Journal of Hematology.
Ron Ram, M.D., of Tel-Aviv University in Israel, and colleagues conducted a systematic review and meta-analysis of 11 published comparative studies reporting results from 2,489 adolescent and young adult patients, aged 16 to 39 years, with ALL. The safety and efficacy of pediatric-inspired induction chemotherapy regimens were compared with conventional-adult chemotherapy.
The researchers found that all-cause mortality at three years was significantly lower for adolescent and young adult patients treated with pediatric-inspired chemotherapy compared with conventional-adult chemotherapy regimens (relative risk [RR], 0.58). Those treated with pediatric-inspired regimens had superior complete remission rates after induction chemotherapy (RR, 1.05; 95 percent confidence interval, 1.01 to 1.10) and improved event-free survival (RR, 1.66). Although nonrelapse mortality was similar between the two groups, the relapse rate was significantly lower in pediatric-inspired regimen-treated adolescents and young adults (RR, 0.51).
"Pediatric-inspired regimens are superior to conventional-adult chemotherapy in adolescent and young adult ALL patients," the authors write. "Further randomized controlled studies to investigate this approach in adult ALL patients are warranted.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top