Low Vitamin D Linked to Poorer Outcomes in Lung Recipients

Vitamin D deficiency linked to increased rates of acute rejection, infection, death at one year

THURSDAY, May 3 (HealthDay News) -- For lung transplant recipients, 25-hydroxyvitamin D (25[OH]D) deficiency is associated with increased incidence of acute rejection and infection, and deficiency at one year after transplant is linked with increased mortality, according to a study published online March 5 in The Journal of Heart and Lung Transplantation.

To investigate the correlation between vitamin D levels and outcomes after lung transplant, Erin M. Lowery, M.D., from the Loyola University Medical Center in Maywood, Ill., and colleagues reviewed data from a cohort of 102 lung transplant recipients. All participants had 25(OH)D levels drawn within 100 days before or after transplant.

The researchers found that, in the near-transplant period, 80 percent of lung transplant recipients were 25(OH)D deficient and 20 percent were not deficient. Compared with the non-deficient group, the deficient group experienced more frequent episodes of acute cellular rejection (mean, 1.27 versus 0.52), had a higher rejection rate (incident rate ratio [IRR], 2.43), and experienced more frequent infectious episodes (mean, 4.01 versus 2.71). Patients who remained deficient at one year post-transplant had a significantly higher mortality rate than those who were not 25(OH)D deficient (IRR, 4.79).

"We assert that there are multiple benefits to maintaining normal serum vitamin D levels in the lung transplant population, such as decreased frequency of acute rejection and infection and an overall survival benefit," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Meeting the Needs of Family Members of ICU Patients
Critical Care Nursing Quarterly, October/December 2014
Free access will expire on December 22, 2014.


Dealing with the specter of phantom limb pain
Nursing2014 , November 2014
Free access will expire on December 8, 2014.


The Power of Nursing Peer Review
JONA: Journal of Nursing Administration, November 2014
Free access will expire on December 8, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events