View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
FRIDAY, May 4 (HealthDay News) -- For patients with diverse pathologies who undergo endoscopic ultrasonography with fine-needle aspiration, adding fluorescence in situ hybridization (FISH) detection methods to conventional cytology improves the sensitivity of cytology alone for detection of neoplastic lesions, according to a study published in the May issue of Gastroenterology.
To compare the accuracy of conventional cytology with that achieved using digital image analysis and FISH methods to detect neoplasia, Michael J. Levy, M.D., of the Mayo Clinic in Rochester, Minn., and colleagues conducted a prospective study using at least six fine-needle aspiration samples from each of 250 patients, collected during endoscopic ultrasonography.
The researchers tested samples collected from the lymph nodes, pancreas, gastrointestinal lumen wall, periluminal mass, liver, and other miscellaneous sites. Digital image analysis demonstrated a potential lack of utility. FISH combined with conventional cytology was 11 percent more sensitive than cytology alone in detecting malignancy (P = 0.0002), but its specificity was reduced from 100 to 96 percent.
"FISH analysis significantly enhanced the diagnostic sensitivity over conventional cytology alone, despite limited tissue sampling," the authors write. "Our data support the contention that the majority of tested cancers harbor chromosomal alterations, irrespective of the underlying histology."
One author and affiliation disclosed holding a patent and receiving royalties from the sale of the FISH probe set (UroVysion) discussed in this study.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top