Omega-3 Intake Linked With Reduced Plasma β-Amyloid 42

Inverse association between omega-3 fatty acids and Aβ42; no association for other nutrients

WEDNESDAY, May 2 (HealthDay News) -- Higher intake of ω-3 polyunsaturated fatty acid (PUFA) is correlated with lower plasma levels of β-amyloid (Aβ)42, according to a study published online May 2 in Neurology.

To investigate the association between nutrient intake and plasma Aβ40 and 42 levels, Yian Gu, Ph.D., of Columbia University in New York City, and associates conducted a cross-sectional community-based study of 1,219 cognitively healthy subjects older than 65 years of age. Dietary intake of 10 nutrients was examined, and Aβ assays were conducted an average of 1.2 years later.

In unadjusted analyses, the researchers found that higher intake of ω-3 PUFA correlated with lower levels of Aβ40 and Aβ42. The association between ω-3 PUFA and Aβ42 persisted after adjustment, while the association with Aβ40 was attenuated. There was no association between other nutrient levels and plasma Aβ levels.

"Our data suggest that higher dietary intake of ω-3 PUFA is associated with lower plasma levels of Aβ42, a profile linked with reduced risk of incident Alzheimer's disease and slower cognitive decline in our cohort," the authors write.

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