Early Noninvasive Paternity Test Based on SNPs Is Accurate

Test requires only maternal blood and can be performed at as early as 8 weeks

WEDNESDAY, May 2 (HealthDay News) -- A new test, based on single-nucleotide polymorphisms, that only requires a maternal blood sample can correctly identify paternity as early as 8 weeks' gestation, according to a letter published in the May 3 issue of the New England Journal of Medicine.

Xin Guo, Ph.D., from Ravgen in Columbia, Md., and colleagues collected blood samples from 30 pregnant women at 8 to 14 weeks' gestation and compared the genetic profile of fetal DNA in maternal blood with two samples of blood: one from the biological father and one sample from an unrelated man. To prevent the release of maternal DNA into the plasma, a fixative was added to the maternal blood samples. Use of single-nucleotide polymorphisms to distinguish fetal DNA from maternal DNA allowed short amplicons to be utilized, thereby minimizing allele dropout. For each pregnant woman, the three samples were processed in a blinded fashion.

The researchers found that the test correctly identified the father in all 30 cases. They note that the probability of identifying all 30 fathers correctly was less than one in a billion.

"Our approach shows that noninvasive prenatal paternity testing can be performed within the first trimester with the use of a maternal blood sample," Guo and colleagues conclude.

Several authors are employees of Ravgen, which supported the study and holds patents and has patents pending for the methods described in the study.

Full Text

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events