Oxygen Treatment Beneficial in Diabetes-Prone Mice

Hyperbaric oxygen therapy cuts diabetes incidence, preserves β-cells in nonobese diabetic mice

TUESDAY, May 8 (HealthDay News) -- Hyperbaric oxygen treatment of a preclinical diabetes mouse model reduces the incidence of diabetes and preserves insulin-producing β-cells, according to a study published online May 7 in Diabetes.

Gaetano Faleo, Ph.D., from the University of Miami, and colleagues examined the effect of one hour of daily hyperbaric oxygen therapy with 100 percent oxygen on the development of autoimmune diabetes in nonobese diabetic mice.

The researchers found that the incidence of cyclophophamide-induced diabetes fell from 85.3 to 48 percent. The incidence of spontaneous diabetes dropped from 85 percent in controls to 65 percent in treated mice. In mice with prediabetes, treatment with hyperbaric oxygen was associated with reduced insulitis, reduced T-cell proliferation in vitro, elevated CD62L expression in T-lymphocytes, decreased costimulation markers (CD40, DC80, and CD86), and major histocompatibility complex class II expression in dendritic cells. However, hyperbaric oxygen was less effective once autoimmunity was established. Compared with controls, hyperbaric oxygen therapy reduced apoptosis and increased proliferation of insulin+ cells.

"Hyperbaric oxygen therapy reduces autoimmune diabetes incidence in nonobese diabetic mice via increased resting T-lymphocytes and reduced activation of dendritic cells with preservation of β-cell mass resulting from decreased apoptosis and increased proliferation," Faleo and colleagues conclude.

Several authors disclosed financial ties to Converge Biotech Inc., which partially funded the study.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Meeting the Needs of Family Members of ICU Patients
Critical Care Nursing Quarterly, October/December 2014
Free access will expire on December 22, 2014.


Dealing with the specter of phantom limb pain
Nursing2014 , November 2014
Free access will expire on December 8, 2014.


The Power of Nursing Peer Review
JONA: Journal of Nursing Administration, November 2014
Free access will expire on December 8, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events