Rituximab Little Use in Resistant Idiopathic Nephrotic Syndrome

Drug does not reduce proteinuria in combination with prednisone, calcineurin inhibitors

FRIDAY, May 11 (HealthDay News) -- The anti-CD20 monoclonal antibody, rituximab, added to prednisone and calcineurin inhibitors, does not provide any additional benefit in terms of reduced proteinuria in the treatment of children with resistant idiopathic nephrotic syndrome (INS), according a study published online May 10 in the Journal of the American Society of Nephrology.

Alberto Magnasco, M.D., of the IRCCS Giannina Gaslini Children's Hospital in Genoa, Italy, and colleagues conducted an open-label, randomized, controlled trial involving 31 children aged 2 to 16 years with INS unresponsive to prednisone plus calcineurin inhibitors to investigate whether rituximab has any efficacy in these patients. All patients continued receiving prednisone and calcineurin inhibitors, and one group received adjuvant rituximab.

The researchers found that the children receiving rituximab did not have a statistically significant reduction in proteinuria at three months (change, −12 percent; P = 0.77 in a covariance model adjusted for baseline proteinuria). The results were not altered after further adjustment for previous remission and interaction terms.

"In conclusion, our study suggests that rituximab is not effective in forms of INS resistant to steroids and calcineurin inhibitors," the authors write. "This seems to be especially true in children with INS who never responded to standard drugs. Further studies may be necessary in children with delayed-resistant forms of INS."

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Dogs as Pets, Visitors, Therapists and Assistants
Home Healthcare Nurse, November/December 2014
Free access will expire on January 5, 2015.


Tracheostomy Care
Nursing2014 Critical Care, November 2014
Free access will expire on December 22, 2014.


Effective management of ARDS
The Nurse Practitioner, 13December 2014
Free access will expire on December 22, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events