Depression Found to Increase Risk of Death in Diabetes

Effect of depression independent of previous cardiovascular events, glycemia control assignment

FRIDAY, June 1 (HealthDay News) -- For patients with type 2 diabetes, depression is associated with an increased risk of all-cause mortality, regardless of previous cardiovascular disease, according to a study published online May 22 in Diabetes Care.

Mark D. Sullivan, M.D., Ph.D., from the University of Washington School of Medicine in Seattle, and colleagues investigated the impact of depression on cardiovascular disease outcomes in type 2 diabetes. Responses to the Patient Health Questionnaire (PHQ)-9 measure of depression symptoms were collected from 2,053 participants from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study.

The researchers found that, in fully adjusted models, depression was not significantly associated with the primary composite outcome of cardiovascular death, nonfatal heart attack, or stroke (hazard ratio [HR], 1.53; 95 percent confidence interval [CI], 0.85 to 2.73), or with the ACCORD microvascular composite outcome (HR, 0.93; 95 percent CI, 0.53 to 1.62). For participants with PHQ-identified probable major depression and for those with a PHQ score of ≥10, all-cause mortality was significantly increased (HR, 2.24 and 1.84, respectively). The effect of depression on all-cause mortality was independent of previous cardiovascular events or assignment to intensive or standard glycemia control. There was a borderline significant association between probable major depression and the ACCORD macrovascular end point (HR, 1.42; 95 percent CI, 0.99 to 2.04).

"Depression increases the risk of all-cause mortality and may increase the risk of macrovascular events among adults with type 2 diabetes at high risk for cardiovascular events," the authors write.

The pharmaceutical industry provided study-related medications and equipment.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Abdominal Pain: An Approach to a Challenging Diagnosis
AACN Advanced Critical Care, July/September 2014
Free access will expire on October 13, 2014.


HIPAA Compliance Practice Tips
Professional Case Management, July/August 2014
Free access will expire on September 29, 2014.


Follow the leader: How does “followership” influence nurse burnout?
Nursing Management, August 2014
Free access will expire on September 29, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events