Pathologic Response Prediction of Survival Aided by Tumor Type

When specific tumor type is considered, pathologic complete response more predictive of survival

WEDNESDAY, May 30 (HealthDay News) -- Pathologic complete response (pCR) is more highly predictive of recurrence-free survival (RFS) when specific breast cancer tumor type is factored in, according to a study published online May 29 in the Journal of Clinical Oncology.

To investigate the association between pCR and RFS overall and within receptor subsets, Laura J. Esserman, M.D., from the University of California at San Francisco, and colleagues assessed clinical, imaging, and genomic data from 221 patients with a tumor of ≥3 cm (median, 6.0 cm) who had received neoadjuvant chemotherapy.

The researchers found that, based on a 70-gene prognosis profile, 91 percent of participants were classified as poor risk. Of the participants, 41 percent were hormone receptor (HR) negative and 31 percent were human epidermal growth factor receptor 2 (HER2) positive. Among the 190 patients not treated with neoadjuvant trastuzumab, pCR was highest for patients with HR-negative/HER2-positive tumors (45 percent) and lowest for patients with HR-positive/HER2-negative tumors (9 percent). Achieving pCR was predictive of improved RFS. For 172 patients treated without trastuzumab, patients with pCR had a hazard ratio of 0.29 for RFS when compared to patients with no pCR. On multivariate analysis, when subtype was factored in, pCR was more predictive of RFS, with lower hazard ratios for HR-positive/HER2-negative (hazard ratio, 0.00), HR-negative/HER2-negative (hazard ratio, 0.25), and HER2-positive (hazard ratio, 0.14) subtypes. The predictive value of pCR within subsets was further improved with Ki67.

"pCR is more highly predictive of RFS within every established receptor subset than overall, demonstrating that the extent of outcome advantage conferred by pCR is specific to tumor biology," the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical device industries.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events