Metabolic Syndrome Linked to Arterial Stiffness in CKD

Waist circumference, SBP independent predictors of arterial stiffness in chronic kidney disease

MONDAY, June 4 (HealthDay News) -- For patients with chronic kidney disease (CKD), those with metabolic syndrome (MetS) have increased arterial stiffness but no increase in endothelial dysfunction, compared to those without MetS, according to a study published online May 29 in Diabetes Care.

Pajaree Lilitkarntakul, M.D., from the University of Edinburgh in the United Kingdom, and colleagues assessed carotid-femoral pulse wave velocity (CF-PWV) and flow-mediated dilation (FMD) as measures of arterial stiffness and endothelial dysfunction, respectively, in 113 minimally comorbid CKD patients and 23 matched controls.

The researchers found that there were significant associations for systolic blood pressure (SBP), waist circumference, and plasma glucose with CF-PWV (r², 0.25, 0.09, and 0.09, respectively). FMD was significantly associated with both SBP and waist circumference (r², 0.09 and 0.03, respectively). As the number of risk factors for MetS increased, CF-PWV increased progressively (r² = 0.07). Independent determinants for CF-PWV were SBP and waist circumference, but only SBP predicted FMD.

"CKD patients with MetS have increased arterial stiffness compared with those without MetS but no difference in endothelial function," the authors write. "Although blood pressure remains the strongest determinant of both arterial stiffness and endothelial dysfunction, the presence of MetS or its risk factors is also an important determinant of arterial stiffness in this CKD cohort."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

What internal motivators drive RNs to pursue a BSN?
Nursing2014 , October 2014
Free access will expire on November 24, 2014.


Breast Cancer Risk Assessment in Primary Care
MCN, The American Journal of Maternal/Child Nursing, September/October 2014
Free access will expire on November 10, 2014.


Nurses spurring innovation
Nursing Management, October 2014
Free access will expire on November 10, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events