View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
THURSDAY, June 7 (HealthDay News) -- A series of 12 predictive rules that combines existing scoring systems in patients with acute pancreatitis improves the accuracy of predicting persistent organ failure, according to a study published in the June issue of Gastroenterology.
Rawad Mounzer, M.D., from the University of Pittsburgh, and colleagues compared the accuracy of scoring systems created to predict which patients with pancreatitis will develop persistent organ failure (cardiovascular, pulmonary, and/or renal failure lasting 48 hours or more). Data were collected from a training cohort (256 patients) and a validation cohort (397 patients). On admission and 48 hours later, nine clinical scores were calculated. Twelve predictive rules which combined these scores were developed.
The researchers found that, in the training and validation cohorts, existing scoring systems showed modest accuracy (area under the curve [AUC] training cohort, 0.62 to 0.84; AUC validation cohort, 0.57 to 0.74), with the Glasgow score the best classifier at admission. In each set of patients, serum levels of creatinine and blood urea nitrogen provided similar levels of discrimination. In both cohorts, use of the 12 predictive rules increased accuracy (AUC training cohort, 0.92; AUC validation cohort, 0.84).
"The existing scoring systems seem to have reached their maximal efficacy in predicting persistent organ failure in acute pancreatitis," the authors write. "Sophisticated combinations of predictive rules are more accurate but cumbersome to use, and therefore of limited clinical use."
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top