Susceptibility Loci Identified for Migraine Without Aura

Associations seen at unique loci and at two previously reported migraine loci

MONDAY, June 11 (HealthDay News) -- Genome-wide association analysis has identified susceptibility loci for migraine without aura, two of which overlap with previously reported migraine loci, according to a study published online June 10 in Nature Genetics.

Tobias Freilinger, M.D., from Klinikum der Universitat München in Munich, Germany, and colleagues performed a genome-wide association study involving 2,326 German and Dutch individuals with migraine without aura and 4,580 matched controls. Candidate variants were replicated in an independent set of 2,508 individuals with migraine without aura and 2,652 matched controls.

The researchers found that single nucleotide polymorphisms at two loci (MEF2D and TGFBR2) were strongly associated with migraine without aura, and an additional two loci (PHACTR1 and ASTN2) showed weaker evidence of association. They also replicated associations of two loci that had previously been associated with migraine with aura (TRPM8 and LRP1).

"This study identifies the first susceptibility loci for migraine without aura, thereby expanding our knowledge of this debilitating neurological disorder," Freilinger and colleagues conclude.

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