T Cell Receptor 'Clonotypes' Key to HIV-1 Infection Control

Distinct clonotypes seen for controllers, progressors; differ in their ability to inhibit viral replication

WEDNESDAY, June 13 (HealthDay News) -- The association of particular human leukocyte antigens (HLAs) with the ability of some individuals to control HIV-1 infection is modulated by clones of T cell antigen receptors (TCRs) with specific phenotypes (clonotypes), according to a study published online June 10 in Nature Immunology.

To examine how HLA-B*27 and HLA-B*57 can control HIV-1 infection in some individuals (controllers) but not others (progressors), Huabiao Chen, Ph.D., from the Massachusetts Institute of Technology in Boston, and colleagues examined the responses of restricted CD8+ T cells from treatment-naive controllers and progressors to HIV-1 and viral epitopes.

The researchers found that distinct TCR clonotypes were associated with better control of HIV-1 replication in vitro, enhanced cross-reactivity to epitope variants, and increased loading and delivery of perforin. This correlated with the distinct ability of controllers and progressors to inhibit viral replication via targeting of the immunodominant epitope of the group-associated antigen of HIV-1. In controllers and progressors, clonotype-specific differences were noted in antiviral efficacy for an immunodominant HLA-B*57-restricted response. The most effective clonotypes were dominantly selected in vivo in the controllers, while the least effective were dominantly selected in the progressors.

"Thus, the efficacy of such so-called 'protective alleles' is modulated by specific TCR clonotypes selected during natural infection, which provides a functional explanation for divergent HIV-1 outcomes," Chen and colleagues conclude.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events